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Updated: Apr 14, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Aggressive behaviour of metastatic melanoma in a patient with neurofibromatosis type 1
Robert W Foley1, Robert M Maweni2, Aurelie Fabre3
1School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland ; Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Belfield, Dublin 4, Ireland.
Abstract:
Malignant melanoma is a common skin neoplasm bearing poor prognosis when presenting with metastases. Rarely melanoma metastases present without an identifiable primary cutaneous lesion despite exhaustive workup. We describe the case of a solitary lung metastasis in a patient with neurofibromatosis type 1 without an identifiable primary tumour. The rapid progression of this malignant neoplasm that led to the patient's death within 1 year is described.

