Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same author

Infection-specific long-chain fatty acid metabolism as a broad anti-enterovirus target.

bioRxiv : the preprint server for biology·2026
Same author

A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralization.

bioRxiv : the preprint server for biology·2026
Same author

Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle-mediated infection in humanized liver chimeric mouse models.

Science advances·2026
Same author

Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferon.

bioRxiv : the preprint server for biology·2026
Same author

Hepatitis B virus covalently closed circular DNA formation in murine hepatic cells uncovers a late entry block.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Apr 14, 2026

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro
08:41

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro

Published on: March 28, 2025

2.3K

New Methods in Tissue Engineering: Improved Models for Viral Infection.

Vyas Ramanan1, Margaret A Scull2, Timothy P Sheahan2

  • 1Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Cambridge, Massachusetts 02139.

Annual Review of Virology
|April 21, 2015
PubMed
Summary
This summary is machine-generated.

Tissue engineering offers advanced models for studying viral infections, overcoming limitations of traditional cell cultures and animal models. These innovative approaches enhance understanding of virus-host interactions and disease progression.

Keywords:
cell-cell interactionscomplexityhepatotropic viruseshost-pathogen interactionspatterningprimary cells

More Related Videos

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2
09:13

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Published on: October 24, 2016

8.6K
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.9K

Related Experiment Videos

Last Updated: Apr 14, 2026

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro
08:41

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro

Published on: March 28, 2025

2.3K
Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2
09:13

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Published on: October 24, 2016

8.6K
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.9K

Area of Science:

  • Virology
  • Tissue Engineering
  • Infectious Diseases

Background:

  • Current viral infection models (tissue culture, animal models) have significant limitations.
  • Tissue culture lacks in vivo complexity, while animal models have restricted susceptibility and manipulation challenges.
  • Developing advanced model systems is crucial for understanding virus-host biology.

Purpose of the Study:

  • To review the state of the art in tissue engineering for virology.
  • To explore how tissue engineering can address shortcomings of existing viral infection models.
  • To discuss future applications of tissue engineering in virology, focusing on hepatotropic viruses.

Main Methods:

  • Review of current tissue engineering techniques relevant to virology.
  • Analysis of how engineered tissues can model in vivo viral life cycles.
  • Discussion of challenges and solutions for implementing tissue-engineered viral infection models.

Main Results:

  • Tissue engineering can create models combining the benefits of cell culture and animal models.
  • Engineered tissues offer improved recapitulation of viral infection complexity and host responses.
  • Potential for enhanced molecular manipulation and analysis in these advanced models.

Conclusions:

  • Tissue engineering holds significant promise for advancing the study of viral infections.
  • These models can provide deeper insights into virus-host interactions, particularly for hepatotropic viruses.
  • Overcoming current challenges will unlock new avenues for therapeutic development and disease research.