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Efficacy and Safety of Human Growth Hormone in Idiopathic Short Stature

Songxue Tao1, Guimei Li, Qian Wang

  • 1Department of Pediatrics, Shandong Provincial Hospital affiliated to Shandong University, 9677 Jingshi Road, Jinan, 250014, People's Republic of China.

Indian Journal of Pediatrics
|April 21, 2015
PubMed

Insights

Medium doses of recombinant human growth hormone (rhGH) effectively increase growth rate and improve predicted adult height in prepubescent girls with idiopathic short stature (ISS). This treatment did not accelerate bone maturation or cause serious side effects over two years.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Skeletal Development

Background:

  • Idiopathic short stature (ISS) affects prepubescent children, impacting growth and potential adult height.
  • Recombinant human growth hormone (rhGH) is a therapeutic option for growth disorders.
  • Optimizing rhGH dosage and safety in ISS requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy and safety of a medium dose of rhGH in prepubescent girls with ISS.
  • To assess the impact of rhGH on growth rate, height standard deviation score (HtSDS), and expected adult height (PAH).
  • To determine if rhGH treatment affects bone age (BA) progression.

Main Methods:

  • A prospective study involving 51 prepubescent girls with ISS.
  • Randomized assignment to a treatment group (n=27) receiving rhGH (0.35-0.42 mg·kg⁻¹·wk⁻¹) or a control group (n=24) without rhGH therapy.
  • Analysis of height, growth rate, HtSDS, BA, PAH, and adverse events over two years.

Main Results:

  • Significantly higher growth rates and HtSDS were observed in the rhGH treatment group compared to the control group during both study years.
  • The expected adult height was significantly improved in the treatment group after two years.
  • Bone age progression did not significantly differ between the treatment and control groups.

Conclusions:

  • Short-term, medium-dose rhGH therapy is effective in increasing growth rate and improving expected adult height in prepubescent girls with ISS.
  • The observed benefits were achieved without accelerating bone maturation.
  • No serious adverse reactions were associated with rhGH treatment during the two-year study period.
Abstract

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