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Related Experiment Videos

Ciprofloxacin intravenous dose variance.

H Lode1, G Hoffken, K Borner

  • 1Medical Department, Klinikum Steglitz, Freie Universitat Berlin, Federal Republic of Germany.

The American Journal of Medicine
|November 30, 1989
PubMed
Summary

Intravenous ciprofloxacin showed minimal serum concentration variability in healthy volunteers but greater variability in patients, even those with kidney issues. Non-measurable concentrations were not observed in any patient group during treatment.

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Area of Science:

  • Pharmacokinetics and Drug Metabolism
  • Clinical Pharmacy
  • Infectious Diseases

Background:

  • Ciprofloxacin is a widely used fluoroquinolone antibiotic administered intravenously.
  • Understanding drug concentration variability is crucial for optimizing therapeutic efficacy and safety.
  • Previous studies in healthy volunteers indicated low variability in ciprofloxacin serum concentrations.

Purpose of the Study:

  • To compare the variability of serum ciprofloxacin concentrations between healthy volunteers and patients receiving intravenous treatment.
  • To investigate the impact of renal insufficiency on ciprofloxacin serum concentration variability in patients.

Main Methods:

  • Analysis of serum ciprofloxacin concentrations from studies involving healthy volunteers (single- and multiple-dose).

Related Experiment Videos

  • Analysis of serum ciprofloxacin concentrations from patient populations undergoing intravenous ciprofloxacin therapy.
  • Comparison of concentration variability across different study groups, including patients with varying renal function.

    • Main Results:

    • Healthy volunteers exhibited limited variability in serum ciprofloxacin concentrations across single- and multiple-dose regimens.
    • Patients receiving intravenous ciprofloxacin demonstrated significantly greater variability in serum concentrations compared to volunteers.
    • This increased variability was also observed in patients with different degrees of renal insufficiency.

    Conclusions:

    • Intravenous ciprofloxacin dosing leads to more variable serum concentrations in patients than in healthy volunteers.
    • Renal insufficiency does not appear to be the sole factor driving the observed variability in patient populations.
    • Non-measurable ciprofloxacin serum concentrations were not documented in patients during intravenous treatment, suggesting consistent systemic absorption.