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How evolution tells us to induce allotolerance.

Walter Gottlieb Land1

  • 1From Molecular ImmunoRheumatology, INSERM, UMR S 1109, LabEx Transplantex, Faculty of Medicine, University of Strasbourg, Strasbourg, France.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|April 21, 2015
PubMed
Summary
This summary is machine-generated.

The danger/injury theory explains immunity, stating that cell stress and tissue injury, not "non-self" alone, trigger immune responses. Evolution shows immune tolerance to harmless "non-self" like microbes and fetuses, crucial for survival and reproduction.

Area of Science:

  • Immunology
  • Evolutionary Biology
  • Microbiology

Background:

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  • Modern immunology is shaped by three main theories: clonal selection, pattern recognition, and danger/injury.
  • The danger/injury theory posits that cell stress and tissue damage, not 'non-self' antigens alone, initiate immune responses, including alloimmunity.
  • This contrasts with earlier theories suggesting 'non-self' inherently triggers immunity.