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Updated: Apr 14, 2026

Synthesis of an Intein-mediated Artificial Protein Hydrogel
Published on: January 27, 2014
Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase
Jingming Zhao1, Anna Kajetanowicz, Thomas R Ward
1Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland. thomas.ward@unibas.ch.
Abstract:
An artificial metathesase results from incorporation of an Hoveyda-Grubbs catalyst bearing an arylsulfonamide anchor within human carbonic anhydrase II. The optimization of the catalytic performance is achieved upon combining both chemical and genetic means. Up to 28 TONs were obtained within four hours under aerobic physiological conditions.
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