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Updated: Apr 14, 2026

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome
Published on: April 2, 2018
HMGA1-pseudogene expression is induced in human pituitary tumors
Francesco Esposito1, Marco De Martino, Daniela D'Angelo
1a Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche; Scuola di Medicina e Chirurgia di Napoli; Università degli Studi di Napoli "Federico II" , Naples , Italy.
New research reveals that High Mobility Group A1 (HMGA1) pseudogenes, HMGA1P6 and HMGA1P7, promote pituitary tumor growth. Their increased expression correlates with HMGA1 levels, suggesting a role in pituitary tumorigenesis.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- High Mobility Group A (HMGA) proteins are implicated in human pituitary tumors.
- HMGA1 overexpression is observed in pituitary tumors, unlike HMGA2, without locus alterations.
Purpose of the Study:
- To investigate the role of HMGA1 pseudogenes (HMGA1P6 and HMGA1P7) in pituitary tumorigenesis.
- To determine the correlation between HMGA1 pseudogene expression and HMGA1 mRNA levels in pituitary adenomas.
Main Methods:
- Correlation analysis of HMGA1 pseudogene and HMGA1 mRNA levels in human pituitary adenomas.
- Functional studies using mouse pituitary tumor cell lines to assess pseudogene effects on proliferation and migration.
Main Results:
- HMGA1 pseudogene expression correlates with HMGA1 mRNA levels in growth hormone and nonfunctioning pituitary adenomas.
- HMGA1 pseudogenes enhance pituitary tumor cell proliferation and migration.
- Pseudogene upregulation may inhibit microRNA-mediated repression of HMGA1.
Conclusions:
- HMGA1 pseudogenes (HMGA1P6 and HMGA1P7) may contribute to pituitary tumorigenesis by increasing HMGA1 levels.
- These pseudogenes represent potential therapeutic targets for pituitary tumors.
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