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Association of VEGF genetic polymorphisms with recurrent spontaneous abortion risk: a systematic review and
Xinghua Xu1, Chigang Du2, Huihui Li3
1Department of Gynecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, 252000, China; Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250021, China; The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, 250021, China.
Background:
Studies of the associations between the genetic polymorphisms of the vascular endothelial growth factor (VEGF) gene and recurrent spontaneous abortion (RSA) have revealed conflicting results. The present meta-analysis was performed to provide a more precise estimation of these relationships and to explore potential sources of heterogeneity that may have influenced the reported disparities.
Methods:
An extensive literature search for relevant studies was conducted on PubMed, Embase, and The Cochrane Library through June 6, 2014. Crude odds ratio (OR) with 95% confidence intervals were calculated.
Results:
10 case-control studies including 1,832 RSA patients and 2,271 healthy controls were identified. Meta-analysis indicated that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms in the VEGF gene correlated with elevated RSA risk. The rs1570360 variant was statistically significantly relevant to RSA risk among non-Asian populations. Interestingly, the rs3025039 variant was statistically significantly relevant to RSA risk among Asian populations.
Conclusions:
The current meta-analysis indicates that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms increase RSA susceptibility. Moreover, rs1570360 and rs3025039 polymorphisms may play various roles in RSA susceptibility in various geographic groups.
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