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Human alpha- and beta-calcitonin gene-related peptides are vasodilators in human chorionic plate vasculature
K F Firth1, F Broughton Pipkin
1Department of Obstetrics and Gynecology, University Hospital, Nottingham, England.
American Journal of Obstetrics and Gynecology
|November 1, 1989
Abstract:
Calcitonin gene-related peptide receptors are known to be present in the placenta. We studied the effect of alpha- or beta-calcitonin gene-related peptide or carrier on human chorionic plate arteries preconstricted with angiotensin II. Both forms of calcitonin gene-related peptides evoked dose-dependent relaxation, the magnitude of which was proportional to the initial response to angiotensin II.