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Related Concept Videos

Continuous Renal Replacement Therapy01:30

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Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
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Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
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Acute Kidney Injury V: Interprofessional Care01:20

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
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Related Experiment Video

Updated: Apr 14, 2026

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
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Pediatric continuous renal replacement: 20 years later.

Claudio Ronco1, Zaccaria Ricci

  • 1Department of Nephrology, Dialysis and Transplantation, S. Bortolo Hospital, Vicenza, Italy.

Intensive Care Medicine
|April 21, 2015
PubMed
Summary
This summary is machine-generated.

Continuous renal replacement therapy (CRRT) has evolved significantly over 20 years, improving outcomes for critically ill children with acute kidney injury (AKI). Modern technology now allows for easier and safer application of CRRT in pediatric intensive care units.

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Area of Science:

  • Pediatric Critical Care Nephrology
  • Renal Replacement Therapies
  • Pediatric Intensive Care

Background:

  • Continuous renal replacement therapy (CRRT) was first used in children over 20 years ago, initially as continuous arteriovenous hemofiltration.
  • Early CRRT lacked specialized equipment, relying on less advanced technology for critically ill children.

Purpose of the Study:

  • To review the evolution of CRRT in pediatric critical care over the past two decades.
  • To highlight the redefinition and recognition of acute kidney injury (AKI) as a significant syndrome in critically ill children.
  • To discuss advancements in technology and their impact on managing pediatric AKI.

Main Methods:

  • Review of historical advancements in CRRT technology, including circuit rheology and filter materials.
  • Analysis of the changing understanding and classification of acute kidney injury (AKI) in pediatric populations.
  • Discussion of the development of novel, pediatric-specific CRRT technology.

Main Results:

  • CRRT has advanced from basic hemofiltration to sophisticated systems incorporating dialysis for increased efficiency.
  • Acute kidney injury (AKI) is now recognized as a distinct syndrome associated with mortality in critically ill children.
  • New technologies specifically designed for pediatric patients have made CRRT feasible and accessible for infants and children.

Conclusions:

  • Significant progress in critical care nephrology has occurred over 20 years, addressing both clinical and technical challenges in pediatric CRRT.
  • Severe pediatric AKI can now be effectively managed with advanced dialysis machines, promising improved patient outcomes.
  • The field of pediatric critical care nephrology has matured, with dedicated technologies enhancing the care of critically ill neonates and children.