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Updated: Apr 14, 2026
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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
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Extracellular vesicles and atherosclerotic disease
Dimitry A Chistiakov1, Alexander N Orekhov, Yuri V Bobryshev
1The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA.
Cellular and Molecular Life Sciences : CMLS
|April 21, 2015
Summary
Circulating extracellular vesicles (EVs) are key messengers carrying biomolecules. These vesicles show promise as diagnostic biomarkers and therapeutic vehicles for cardiovascular diseases.
Area of Science:
- Biochemistry
- Cell Biology
- Cardiovascular Research
Background:
- Circulating extracellular vesicles (EVs) are diverse vesicular structures.
- EVs function as intercellular messengers, transporting proteins, DNA, and RNA.
- EV cargo varies with microenvironmental stimuli, particularly in inflammatory conditions.
Purpose of the Study:
- To explore the role of circulating EVs in cardiovascular pathology.
- To investigate the diagnostic and therapeutic potential of EVs in cardiovascular diseases.
Main Methods:
- Characterization of EV populations (exosomes, microvesicles, apoptotic bodies).
- Analysis of EV cargo composition (proteins, nucleic acids).
- Evaluation of EV properties in inflammatory and cardiovascular disease models.
Main Results:
- EVs derived from various cell types exhibit proinflammatory properties in cardiovascular diseases.
- Circulating EVs can stably maintain and deliver diverse biomolecules.
- MicroRNAs within EVs are identified as valuable diagnostic and prognostic biomarkers.
Conclusions:
- Circulating EVs hold significant therapeutic potential for cardiovascular diseases.
- EVs can serve as targeted delivery vehicles for novel therapies.
- EVs represent a promising source for cardiovascular biomarkers.
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