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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:20

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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Long non-coding RNA functions in lung cancer.

Haiwei Sang1, Haihong Liu, Peng Xiong

  • 1Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, Hubei, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|April 22, 2015
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) regulate genes and are implicated in lung cancer. Understanding lncRNA functions offers potential for new diagnostic biomarkers and therapeutic targets in lung cancer treatment.

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Area of Science:

  • Genomic Research
  • Molecular Biology
  • Cancer Biology

Background:

  • Advances in sequencing have revealed numerous long non-coding RNAs (lncRNAs).
  • lncRNAs are increasingly recognized as gene regulators, particularly through translational control.
  • Dysregulation of lncRNAs is linked to human diseases, including lung cancer, a major cause of cancer mortality.

Purpose of the Study:

  • To review the functions of lncRNAs in translational control.
  • To discuss the involvement of lncRNAs in lung cancer through pathways involving p53 and polycomb repressive complex 2 (PRC2).
  • To explore the potential of lncRNAs as diagnostic and prognostic biomarkers and therapeutic targets in lung cancer.

Main Methods:

  • Literature review of recent studies on lncRNAs in genomic research.
  • Analysis of lncRNA roles in translational control mechanisms.
  • Examination of lncRNA involvement in lung cancer pathways, including p53 and PRC2.

Main Results:

  • lncRNAs play significant roles in gene regulation, including translational control.
  • Specific lncRNAs are implicated in the development and progression of lung cancer.
  • lncRNAs interact with key molecules like p53 and PRC2 in carcinogenesis.
  • Modulating lncRNA levels and functions shows potential therapeutic implications.

Conclusions:

  • lncRNAs are crucial regulators with significant roles in lung cancer.
  • lncRNAs hold promise as diagnostic and prognostic biomarkers for lung cancer.
  • Further research into lncRNA functions may lead to novel therapeutic strategies for lung cancer.