Related Experiment Video
Updated: Apr 14, 2026
09:09
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
6.7K
Engineering the nanoparticle-protein interface for cancer therapeutics.
Amir Ata Saie1, Moumita Ray, Morteza Mahmoudi
1Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Cancer Treatment and Research
|April 22, 2015
Summary
Nanoparticles offer promising cancer therapy by delivering functional proteins into cells. Overcoming cytosolic release challenges and understanding protein corona formation are key to advancing this approach.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapy
Background:
- Intracellular protein delivery via nanoparticles is a novel strategy for cancer treatment.
- Challenges include achieving efficient cytosolic release and managing nanoparticle-protein interactions (protein corona).
Purpose of the Study:
- To review current strategies for intracellular protein delivery using nanoparticles.
- To discuss the impact of protein corona on nanoparticle behavior and efficacy.
Main Methods:
- Literature review of recent advancements in nanoparticle-based protein delivery systems.
- Analysis of studies focusing on cytosolic release mechanisms.
- Examination of research on protein corona formation and its consequences.
Main Results:
- Various nanoparticle formulations show potential for protein delivery.
- Cytosolic release remains a significant hurdle.
- Protein corona formation alters nanoparticle biodistribution and cellular uptake.
Conclusions:
- Effective intracellular protein delivery requires overcoming cytosolic release barriers.
- Managing protein corona is crucial for optimizing nanoparticle-based protein therapeutics.
- Further research is needed to enhance the efficiency and safety of these systems.
Related Concept Videos
02:26Protein Networks
4.7K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.7K
02:04Protein-protein Interfaces
15.0K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
15.0K
02:04Protein-Protein Interfaces
4.6K
4.6K
02:57Targeted Cancer Therapies
9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.2K