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Rituximab causing deep ulcerative suppurative vaginitis/pyoderma gangrenosum.

Priya Selva-Nayagam1, Gayle Fischer, Ian Hamann

  • 1Department of Dermatology, Queen Elizabeth Hospital, Adelaide, Australia, pselva@senet.com.au.

Current Infectious Disease Reports
|April 22, 2015
PubMed
Summary
This summary is machine-generated.

Rituximab treatment for B cell non-Hodgkin's lymphoma may cause pyoderma gangrenosum (PG), a rare condition leading to severe vulvovaginal ulcers. This study details six cases, highlighting rituximab as a likely cause.

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Area of Science:

  • Dermatology
  • Gynecology
  • Oncology

Background:

  • Pyoderma gangrenosum (PG) is a rare ulcerative condition.
  • Vulvovaginal PG is exceptionally uncommon, often presenting with severe symptoms.

Purpose of the Study:

  • To describe cases of vulvovaginal pyoderma gangrenosum in patients treated with rituximab.
  • To investigate the association between rituximab and vulvovaginal PG.
  • To review existing literature and differential diagnoses for vulvovaginal PG.

Main Methods:

  • Case series of six patients with vulvovaginal PG.
  • Review of medical literature on vulvovaginal PG.
  • Analysis of clinical presentation and treatment history.

Main Results:

  • Six patients (age 50-74) developed vulvovaginal PG while undergoing rituximab therapy for B cell non-Hodgkin's lymphoma.
  • Symptoms included severe pain, discharge, and large, deep purulent ulcers extending into the vagina.
  • Symptoms persisted for 2-24 months.

Conclusions:

  • Rituximab is a potential cause of pyoderma gangrenosum in the vulvovaginal region.
  • Early recognition and consideration of rituximab as an etiology are crucial for managing vulvovaginal PG.
  • Further research is needed to elucidate the exact mechanism linking rituximab to PG.