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Updated: Apr 14, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Published on: August 16, 2018

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GABAA receptor α2 subtype activation suppresses retinal spreading depression

M Wang1, Y Li2, Y Lin3

  • 1Centre for Neuroscience, Xi'an Jiaotong-Liverpool University (XJTLU), Suzhou 215123, China; Department of Biological Sciences, XJTLU, Suzhou 215123, China.

Neuroscience
|April 22, 2015
PubMed
Summary

Cortical spreading depression (SD), a migraine cause, is reduced by GABAA receptor activation. This study found the α2 subtype plays a key role in SD, suggesting it as a potential migraine drug target.

Keywords:
GABA(A) receptorTPA023chick retinacortical spreading depressionmigraineα2

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