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Updated: Apr 14, 2026
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
Immunological parameters as a new lead in the diagnosis of ovarian cancer
T Baert1, D Timmerman2, I Vergote1
1UZ Leuven, Gynaecology and Obstetrics, Herestraat 49, 3000 Leuven, Belgium. ; Department of Oncology, Leuven Cancer Institute, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Abstract:
Ovarian cancer is the leading cause of pelvic gynecological cancer death in Europe. Prognosis is poor in women diagnosed at stage III to IV or in case disease recurs. Platin-based chemotherapy and radical surgery have already improved prognosis significantly. Novel strategies in the treatment of ovarian cancer are being searched for. The study of the immune system as a valuable parameter in the development of ovarian cancer has been neglected for a long time. Nevertheless, this is a field in full progression and might open new perspectives in the diagnosis and prognosis of ovarian cancer patients and could lead to a more motivated choice of targeted therapies.
