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Perinatal asphyxia: a review from a metabolomics perspective
Claudia Fattuoni1, Francesco Palmas2, Antonio Noto3
1Department of Chemical and Geological Sciences, University of Cagliari, Cagliari I-09042, Italy. cfattuon@unica.it.
Molecules (Basel, Switzerland)
|April 22, 2015
Summary
Perinatal asphyxia, a birth-related oxygen deprivation, affects millions of newborns. Metabolomics offers a promising approach to understand its mechanisms and identify biomarkers for better monitoring and assessment of hypoxic-ischemic encephalopathy (HIE).
Area of Science:
- Neonatology
- Perinatal Medicine
- Biochemistry
Background:
- Perinatal asphyxia is oxygen deprivation around birth, affecting 4 million neonates globally, with 1 million deaths.
- It can lead to hypoxic-ischemic encephalopathy (HIE), causing neurological damage or organ impairment.
- Current diagnostic and treatment strategies for HIE remain challenging due to multifactorial causes and debated resuscitation guidelines.
Purpose of the Study:
- To review the application of metabolomics in understanding perinatal asphyxia.
- To explore the potential of metabolomics in identifying biomarkers for HIE.
- To assess the current state of metabolomics research in both animal and human models of perinatal asphyxia.
Main Methods:
- Literature review of metabolomics studies on perinatal asphyxia.
- Analysis of research involving animal models.
- Examination of studies conducted on human neonates.
Main Results:
- Metabolomics has emerged as a valuable tool for monitoring and assessing perinatal asphyxia.
- This approach aids in identifying potential biomarkers associated with asphyxia events and HIE.
- Research indicates the utility of metabolomics in both preclinical (animal) and clinical (human) settings.
Conclusions:
- Metabolomics provides critical insights into the complex pathological mechanisms of perinatal asphyxia.
- It holds significant potential for improving the early detection and management of HIE.
- Further research utilizing metabolomics is crucial for defining optimal treatments and improving outcomes for affected neonates.
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