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Related Experiment Videos

Carbohydrate fermentation by gut microflora in preterm neonates.

V Walker1, G A Mills, M A Hall

  • 1Department of Clinical Biochemistry, Southampton University.

Archives of Disease in Childhood
|October 1, 1989
PubMed
Summary

Preterm infants show unusual organic acid excretion due to gut issues. This study identifies novel metabolites like acetoin in their urine, linked to carbohydrate fermentation.

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Area of Science:

  • Neonatal Medicine
  • Metabolomics
  • Gastroenterology

Background:

  • Preterm infants often experience gastrointestinal dysregulation.
  • Understanding their metabolic profiles is crucial for health management.

Purpose of the Study:

  • To investigate organic acid excretion patterns in preterm infants.
  • To identify novel urinary metabolites and their origins.

Main Methods:

  • Urine samples collected weekly from 52 preterm infants.
  • Analysis performed using capillary gas chromatography-mass spectrometry.

Main Results:

  • 2,3-butanediol excreted by 18 infants (12 <33 weeks, 6 between 33-36 weeks).
  • Acetoin, a precursor, found in 6 very immature infants.

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  • Other rare metabolites detected: methylmalonic acid, ethylmalonic acid, and D-lactic acid.
  • Acetoin identified in urine for the first time.

    • Conclusions:

    • Excretion linked to increased intestinal permeability and gut micro-organism colonization.
    • Findings support carbohydrate fermentation in the preterm infant gut.
    • Identified metabolites offer insights into preterm infant metabolic health.