Association between the CX3CR1 gene V249I polymorphism and delayed kidney allograft function

Area of Science:

• Immunogenetics
• Transplantation Science
• Molecular Medicine

Background:

• Fractalkine (CX3CL1) is a chemokine involved in cell adhesion and migration.
• The CX3CR1 gene encodes the fractalkine receptor.
• Genetic variations in CX3CR1 may influence transplant outcomes.

Purpose of the Study:

• To investigate the association between the CX3CR1 V249I (rs3732379) single nucleotide polymorphism (SNP) and renal allograft function.
• To determine if specific CX3CR1 genotypes predict delayed graft function (DGF), acute rejection (AR), or chronic allograft dysfunction (CAD).

Main Methods:

• A cohort of 270 Caucasian kidney allograft recipients was studied.
• Genotyping for the CX3CR1 V249I (rs3732379) SNP was performed.
• Clinical data including recipient demographics, DGF, AR, and CAD were recorded and analyzed.

Main Results:

• The CC genotype of the CX3CR1 V249I SNP was significantly associated with an increased risk of DGF (OR = 2.17; p = 0.0042).
• Multivariate analysis confirmed the CC genotype as an independent predictor of higher DGF risk.
• No significant differences in genotype or allele distribution were observed for AR or CAD.

Conclusions:

• The CX3CR1 V249I (rs3732379) SNP CC genotype is associated with an elevated risk of DGF after kidney transplantation.
• This genetic polymorphism may serve as a predictive marker for early post-transplant complications.
• Further research could explore targeted interventions based on CX3CR1 genotype.