Related Experiment Video
Updated: Apr 14, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Evolution of systemic hypertension in Pakistani population.
1Department of Paediatric Cardiology, National Institute of Cardiovascular Diseases, Karachi.
Essential hypertension is rising in Pakistan despite lower BMI. Factors include genetics, urbanization, and sedentary lifestyles, particularly affecting females and middle-aged individuals.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Essential hypertension prevalence is increasing in Pakistan.
- This trend persists despite generally lower Body Mass Index (BMI) and nutritional profiles in the population.
Purpose of the Study:
- To identify potential factors contributing to the rising prevalence of essential hypertension in Pakistan.
- To review existing population studies conducted within Pakistan.
Main Methods:
- Systematic review of population studies conducted in Pakistan.
- Analysis of demographic and lifestyle factors associated with hypertension.
Main Results:
- Hypertension prevalence is 3-4% in childhood, rising sharply by middle age.
- Key contributing factors identified include genetic susceptibility, female gender, urbanization, obesity, and sedentary lifestyles.
- Cultural practices promoting sedentary behavior in females are also implicated.
Conclusions:
- The rising essential hypertension rates in Pakistan are multifactorial.
- Genetic predisposition combined with environmental and lifestyle changes, particularly urbanization and sedentary habits, are significant drivers.
- Targeted interventions addressing these specific factors are needed.
Related Concept Videos
Hypertension II: Pathophysiology
Hypertension and Regulation of Blood Pressure
Hypertension I: Introduction
Hypertension III: Clinical Manifestations and Diagnostic Studies
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Factors affecting Blood pressure
Physiological Factors:

