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Progressive multiple sclerosis and mood disorders.

Lorena Lorefice1, G Fenu, G Trincas

  • 1Department of Public Health and Clinical and Molecular Medicine, Multiple Sclerosis Center, University of Cagliari, Cagliari, Italy, lorena.lorefice@hotmail.it.

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Summary
This summary is machine-generated.

Patients with progressive multiple sclerosis (PMS) experience major depressive disorder (MDD) more frequently than those with relapsing-remitting MS (RMS). This increased risk is independent of disease duration and disability, emphasizing the need for proactive mood disorder screening in PMS.

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Area of Science:

  • Neurology
  • Psychiatry

Background:

  • Mood disorders are prevalent in multiple sclerosis (MS).
  • The frequency of mood disorders in progressive MS (PMS) requires further investigation.
  • Understanding mood disorder prevalence in different MS phenotypes is crucial for patient management.

Purpose of the Study:

  • To determine the frequency of mood disorders in PMS patients compared to relapsing-remitting MS (RMS) patients.
  • To explore associations between mood disorders, disability, and disease duration in MS.
  • To identify factors influencing mood disorder occurrence in progressive MS.

Main Methods:

  • A cohort of 240 MS outpatients was assessed using DSM-IV criteria and structured interviews (ANTAS-SCID).
  • Disease courses were classified based on established criteria.
  • Statistical analyses included Chi-square tests and logistic regression to identify associations.

Main Results:

  • Major depressive disorder (MDD) was diagnosed in 40% of PMS patients versus 23% of RMS patients.
  • MDD in PMS patients was independent of disease duration and disability.
  • Logistic regression revealed PMS course as a significant factor associated with MDD (OR 2.2, P=0.02).

Conclusions:

  • Patients with progressive multiple sclerosis exhibit a higher incidence of major depressive disorder compared to those with relapsing-remitting MS.
  • The increased prevalence of MDD in PMS is not linked to disease duration or physical disability.
  • These findings underscore the importance of screening for and managing mood disorders, particularly MDD, in the progressive MS population.