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Quantifying dyspigmentation in facial skin ageing: an explorative study.

G Dobos¹, C Trojahn¹, A Lichterfeld¹

¹Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

International Journal of Cosmetic Science

|April 23, 2015

Summary

Facial skin aging in fair-skinned Caucasians leads to increased dyspigmentation. New image analysis parameters effectively quantify these age-related skin color changes.

Keywords:

colour cosmetics skin physiology/structure spectroscopy

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Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Area of Science:

Dermatology
Cosmetic Science
Medical Imaging

Background:

Aging significantly impacts skin melanin, causing dyspigmentation with clinical and psychosocial effects.
While studied in darker skin, age-related pigmentary changes in fair-skinned Caucasians are less understood.

Purpose of the Study:

Investigate age-related facial pigmentation and dyspigmentation in fair-skinned Caucasians (skin phototypes II-III).
Develop and validate new image-processing parameters for quantifying skin dyspigmentation.

Main Methods:

Recruited 24 healthy females across three age groups (30-40, 50-60, 70-80 years).
Measured skin color using Mexameter and Chromameter.
Assessed skin dyspigmentation via clinical evaluation and novel image analysis parameters on cheeks and forehead.

Main Results:

Skin lightness decreased with age.
Clinical dyspigmentation scores positively correlated with chronological age.
RBX®-Brown transformation-based hyperpigmentation and hypopigmentation indices increased with age, while overall pigmentation intensity decreased.

Conclusions:

Demonstrated age-related facial color and dyspigmentation changes in fair-skinned Caucasian females.
Confirmed increased dyspigmentation through clinical scoring and RBX® indices.
Validated the utility of hyper/hypopigmentation indices and overall pigmentation intensity, suggesting RBX® parameters for future studies.