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Published on: June 14, 2018
Late Persistent Increased Putaminal 18F-DOPA Uptake Following Ipsilateral Frontal Resection: Evidence for
Giovanni Morana1, Arnoldo Piccardo, Maria Luisa Garrè
1From the *Neuroradiology Unit, Istituto Giannina Gaslini, Genoa, Italy; †Nuclear Medicine Department, Ospedali Galliera, Genoa, Italy; ‡Neuro-oncology Unit, Istituto Giannina Gaslini, Genoa, Italy; and §Clinical Neurology, Department of Neuroscience, Università di Genova, Genoa, Italy.
Abstract:
We report the finding of late persistent increased putaminal F-3,4-dihydroxyphenylalanine (DOPA) uptake following resection of a high-grade glioma involving the lateral portion of the ipsilateral precentral gyrus. Brain MRI findings were consistent with secondary putaminal degeneration. This F-DOPA PET phenomenon possibly represents elevated presynaptic dopamine function secondary to upregulation of the amino acid decarboxylase (AADC) activity, as a compensatory mechanism in response to cortical injury. In the setting of brain tumor surveillance, focal increased striatal F-DOPA uptake should be carefully interpreted in light of MRI findings and pathological changes related to corticostriatal connections.
