Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

5.7K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.7K
Embryonic Stem Cells00:57

Embryonic Stem Cells

4.1K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.1K
Embryonic Stem Cells00:58

Embryonic Stem Cells

29.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
29.4K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.9K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.9K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.7K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.7K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

24.7K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
24.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Absolute Versus Relative Approaches to Severity Scoring of Histopathologic Findings in Pre-Clinical Toxicology Studies: What's the Difference, and How, When, and Why This Matters.

Toxicologic pathology·2026
Same author

Discrepancies between clinical and radiological assessment of complete remission of rectal cancer after neoadjuvant radiochemotherapy.

Langenbeck's archives of surgery·2026
Same author

Quantifying the Spatial Distribution of Series Resistance in Monolithic Perovskite/Silicon Tandem Solar Cells Using Voltage-Dependent Photoluminescence Imaging.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Editorial: Advances in non-clinical and translational studies: cutting-edge study designs, special technologies, routine pitfalls, background findings and control data.

Frontiers in veterinary science·2026
Same author

A two-tier framework for responsible research on human embryo models.

Cell·2026
Same author

Charting the translational pathway: ISSCR best practices for the development of PSC-derived therapies.

Stem cell reports·2026
Same journal

Safety Assessment of <i>Melaleuca alternifolia</i> (Tea Tree)-Derived Ingredients as Used in Cosmetics.

International journal of toxicology·2026
Same journal

Safety Assessment of Radish Root - Derived Ingredients as Used in Cosmetics.

International journal of toxicology·2026
Same journal

Aldose Reductase Inhibitor, Epalrestat, Suppresses Colorectal Cancer Cell Proliferation Through Complement-Dependent Cytotoxicity.

International journal of toxicology·2026
Same journal

Nonclinical Safety Profiles of mRNA Therapeutics Comprising Unmodified or N1-Methyl-Pseudouridine-Modified Nucleosides Are Similar Following Repeated Administration.

International journal of toxicology·2026
Same journal

Amended Safety Assessment of Naturally-Sourced Clays as Used in Cosmetics.

International journal of toxicology·2026
Same journal

Evaluation of the <i>in vitro</i> Toxicity of Novel Oxime Acetylcholinesterase Reactivators.

International journal of toxicology·2026
See all related articles

Related Experiment Video

Updated: Oct 24, 2025

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
10:16

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

8.0K

Stem Cell Research.

Alan Trounson1, Kyle Kolaja2, Thomas Petersen3

  • 1Monash University, Hudson Institute for Medical Research, Clayton, Victoria, Australia.

International Journal of Toxicology
|April 23, 2015
PubMed
Summary
This summary is machine-generated.

Stem cells show promise in toxicology and regenerative medicine. This symposium explored stem cell models, treatments, and their application in lung regeneration and engineered tissue testing.

Keywords:
advanced therapy medicinal productsinduced pluripotent stem cellregenerative medicinestem cellstem cell therapy

More Related Videos

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

9.4K
Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

14.7K

Related Experiment Videos

Last Updated: Oct 24, 2025

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
10:16

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

8.0K
Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

9.4K
Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

14.7K

Area of Science:

  • Biomedical Science
  • Toxicology
  • Regenerative Medicine

Background:

  • Stem cells are increasingly utilized in basic and toxicological research.
  • Allogeneic stem cell treatments and immunogenicity of protein therapeutics are significant considerations.
  • Regenerative medicine applications for stem cells are rapidly evolving.

Purpose of the Study:

  • To provide an overview of the current state of stem cell applications in toxicology and regenerative medicine.
  • To discuss stem cell models and allogeneic transplantation.
  • To focus on stem cell-based lung regeneration and tissue engineering from a pathologist's viewpoint.

Main Methods:

  • Symposium presentation and discussion.
  • Review of stem cell models and allogeneic treatments.
  • Pathologist's perspective on engineered tissue testing.

Main Results:

  • Overview of stem cell integration into toxicological research.
  • Discussion on challenges in allogeneic stem cell treatments, including immunogenicity.
  • Exploration of stem cell applications in lung regeneration and engineered tissue testing.

Conclusions:

  • Stem cells offer significant potential for toxicological and regenerative medicine applications.
  • Understanding stem cell models and immunogenicity is crucial for therapeutic development.
  • Pathological evaluation is key for assessing engineered tissues in regenerative medicine.