High Familial Correlation in Methylphenidate Response and Side Effect Profile
Michal Gazer-Snitovsky1, Ayelet Brand-Gothelf1, Gal Dubnov-Raz1,2
11 Tel Aviv University, Israel.
Objective:
To examine whether a familial tendency exists in clinical response to methylphenidate.
Method:
Nineteen pairs of siblings or parent-child stimulant-naive individuals with ADHD were prescribed methylphenidate-immediate release, and were comprehensively evaluated at baseline, Week 2, and Week 4, using the ADHD Rating Scale IV, Clinical Global Impression Scale, and the Barkley Side Effects Rating Scale.
Results:
We found significant intraclass correlations in family member response to methylphenidate-immediate release and side effect profile, including emotional symptoms and loss of appetite and weight.
Conclusion:
Family history of response to methylphenidate should be taken into account when treating ADHD.
More Related Videos
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
10:28Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
Related Concept Videos
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Drug Toxicity: Risk factors
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Factors Affecting Drug Response: Overview
Drug toxicity: Idiosyncratic Reactions
