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Related Experiment Video

Updated: Apr 14, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

Tissue engineered periodontal products.

P M Bartold¹, S Gronthos², S Ivanovski³

¹Colgate Australian Clinical Dental Research Centre, Dental School, University of Adelaide, Adelaide, SA, Australia.

Journal of Periodontal Research

|April 23, 2015

Summary

This summary is machine-generated.

Periodontal regeneration remains a challenge, with variable results from current treatments. Tissue engineering offers a promising paradigm, utilizing stem cells, biomaterials, and advanced technologies for future periodontal repair.

Keywords:

cell sheets periodontal ligament periodontal ligament stem cells tissue engineering

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Area of Science:

Periodontology
Regenerative Medicine
Biomaterials Science

Background:

Periodontal regeneration is a key clinical goal for advanced defects caused by periodontitis.
Existing methods like guided tissue regeneration and bone grafting show variable human efficacy.
Tissue engineering emerged as a novel paradigm in the early 2000s for periodontal regeneration.

Purpose of the Study:

To review the progress and current status of tissue engineering in periodontology.
To assess the evolution of periodontal tissue engineering concepts and products.
To identify future directions for achieving complete periodontal regeneration.

Main Methods:

Review of precursor products and historical techniques in periodontal regeneration.
Discussion of fundamental tissue engineering concepts applied to the periodontium.
Exploration of mesenchymal stem cells in biomaterial scaffolds and cell sheet technology.

Main Results:

Animal models show efficacy, but human results for periodontal regeneration are equivocal.
Tissue engineering approaches are advancing, incorporating stem cells and novel technologies.
The field is evolving from early concepts to practical applications.

Conclusions:

Periodontal tissue engineering has progressed significantly since its inception.
Mesenchymal stem cells, biomaterials, and cell sheet technology are key components.
Future advancements may involve CAD/CAM and nanotechnology for enhanced periodontal regeneration.