Related Experiment Video
Updated: Apr 14, 2026
08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
10.5K
Inborn errors in immunity: unique natural models to dissect oral immunity
N M Moutsopoulos1, M S Lionakis2, G Hajishengallis3
1Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA nmoutsop@mail.nih.gov.
Journal of Dental Research
|April 23, 2015
Summary
Inborn errors in immunity reveal critical roles for the interleukin-17 (IL-17) pathway in oral health. Genetic defects illuminate immune functions and susceptibility to fungal infections and inflammatory periodontitis.
Area of Science:
- Immunology
- Genetics
- Oral Health
Background:
- Inborn errors in immunity (IEI) studies have identified novel immune system genes.
- Genomics advancements accelerate the discovery of genetic defects.
- Naturally occurring mutations offer mechanistic insights into human immune function.
Purpose of the Study:
- To discuss how IEI serve as models for understanding human biology and common diseases.
- To highlight the role of the interleukin-17 (IL-17) pathway in oral mucosal immunity.
Main Methods:
- Review of emerging evidence on IEI.
- Analysis of genetic disruptions in patients.
- Focus on the IL-17 axis in oral immune surveillance.
Main Results:
- IEI provide critical insights into human biology and common diseases like those affecting oral health.
- The IL-17 pathway is crucial for oral immune surveillance.
- Disruptions in the IL-17 axis are linked to fungal susceptibility.
- Overactivation of IL-17 pathways is associated with inflammatory periodontitis.
Conclusions:
- IEI are invaluable models for understanding immune system function and disease.
- The IL-17 pathway is a key player in oral health, influencing susceptibility to infections and inflammatory conditions.
- Understanding IL-17 in IEI can inform strategies for managing oral diseases.
Related Concept Videos
01:21Introduction to Innate and Adaptive Immunity
13.1K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
13.1K
01:26Defense Mechanism Against Infection
11.6K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
11.6K
01:22Development of Immunocompetence
1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K
01:25Immunodeficiency Diseases
3.4K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
3.4K
01:20Special Features of Adaptive Immunity
4.6K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
4.6K
01:28Development of the Oral Microbiota
42
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
42