Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measuring cerebral glucose metabolism by chemical exchange-sensitive spin-lock (CESL) MRI of 2-deoxy-D-glucose in rodents.

PloS one·2026
Same author

Comprehensive Magnetic Resonance Imaging Relaxometry of Gadolinium-Based Contrast Agents: A Systematic Study of Transmetallation and Transchelation Processes With Zinc Ions and Heparin.

ChemMedChem·2026
Same author

2-deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after transient focal stroke in the rat.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2025
Same author

RF Heating Effects in CEST NMR with Hyperpolarized <sup>129</sup>Xe Considering Different Spin Exchange Kinetics and Saturation Schemes.

Chemphyschem : a European journal of chemical physics and physical chemistry·2025
Same author

Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer.

Communications chemistry·2024
Same author

Nanomaterials for hyperpolarized nuclear magnetic resonance and magnetic resonance imaging.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology·2023
Same journal

Liver Diffusion Weighted MRI: Effect of Iron Overload on Apparent Diffusion Coefficient.

NMR in biomedicine·2026
Same journal

In Vivo Assessment of Placental Structure and Perfusion in Late-Gestation Pregnancies and Their Association With Fetal Growth.

NMR in biomedicine·2026
Same journal

Reproducibility of Splanchnic Blood Flow Measured Using Phase-Contrast MRI.

NMR in biomedicine·2026
Same journal

Restriction-Weighted Q-Space Trajectory Imaging (ResQ): Toward Mapping Diffusion-Time Effects With Tensor-Valued Diffusion Encoding in Human Prostate Cancer Xenografts.

NMR in biomedicine·2026
Same journal

In Vivo Quantitative Detection of PEGylated Macromolecules by Magnetic Resonance Spectroscopy.

NMR in biomedicine·2026
Same journal

Metabolic Assessment in Human Pluripotent Stem Cell-Derived Cerebral Organoids Using HR-MAS NMR Spectroscopy.

NMR in biomedicine·2026
See all related articles

Related Experiment Video

Updated: Apr 14, 2026

Hyperpolarized Xenon for NMR and MRI Applications
16:20

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

20.3K

Continuous-wave saturation considerations for efficient xenon depolarization.

Martin Kunth1, Christopher Witte1, Leif Schröder1

  • 1ERC Project BiosensorImaging, Leibniz-Institut für Molekulare Pharmakologie (FMP), 13125, Berlin, Germany.

NMR in Biomedicine
|April 23, 2015
PubMed
Summary
This summary is machine-generated.

This study reveals optimal radiofrequency pulse parameters for hyperpolarized Xenon (Xe) chemical exchange saturation transfer (Hyper-CEST) MRI. We derived formulas for optimal pulse duration and strength, enhancing detection of dilute Xe binding sites.

Keywords:
Bloch-McConnellCESTHyper-CESTbiosensorhyperpolarizationquantificationxenon

More Related Videos

Author Spotlight: Advancing Lung Disease Research with Free-Breathing Hyperpolarized Xenon-129 MRI
08:23

Author Spotlight: Advancing Lung Disease Research with Free-Breathing Hyperpolarized Xenon-129 MRI

Published on: November 10, 2023

1.2K
Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases
09:55

Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases

Published on: January 5, 2024

2.0K

Related Experiment Videos

Last Updated: Apr 14, 2026

Hyperpolarized Xenon for NMR and MRI Applications
16:20

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

20.3K
Author Spotlight: Advancing Lung Disease Research with Free-Breathing Hyperpolarized Xenon-129 MRI
08:23

Author Spotlight: Advancing Lung Disease Research with Free-Breathing Hyperpolarized Xenon-129 MRI

Published on: November 10, 2023

1.2K
Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases
09:55

Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases

Published on: January 5, 2024

2.0K

Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Medical Imaging Techniques
  • Chemical Physics

Background:

  • Hyperpolarized Xenon (Xe) enhanced Chemical Exchange Saturation Transfer (Hyper-CEST) is a sensitive NMR method.
  • Detecting low concentrations of Xe binding sites requires precise RF saturation pulse control.
  • Unlike proton MRI, Hyper-CEST requires specific saturation times for maximal effect, which are not easily predicted.

Purpose of the Study:

  • To derive expressions for the optimal saturation pulse length in Hyper-CEST.
  • To identify RF pulse strength and duration that maximize Hyper-CEST signal.
  • To improve the detection sensitivity of dilute Xe binding sites.

Main Methods:

  • Theoretical derivation of optimal saturation pulse parameters.
  • Analysis of Hyper-CEST signal dependence on pulse strength (B1) and duration.
  • Investigation of the influence of Xe exchange rate (k(BA)) and gyromagnetic ratio (γ).

Main Results:

  • Expressions for optimal saturation pulse length were derived.
  • A pulse strength of B1 = 5 k(BA)/γ yields 96% of maximal Hyper-CEST contrast.
  • An optimal pulse strength of B1 = √2 k(BA)/γ simultaneously optimizes amplitude and spectral width.
  • Simplified optimal saturation time expressions were found for extremely low host concentrations.

Conclusions:

  • Precise RF pulse parameters are crucial for maximizing Hyper-CEST signal.
  • The derived expressions provide a guide for optimizing Hyper-CEST experiments.
  • This work enhances the capability of Hyper-CEST for detecting low-concentration Xe binding sites.