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Updated: Apr 14, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
Past and future impact of next-generation sequencing in head and neck cancer
Neeraj Sethi1, Kenneth MacLennan1, Henry M Wood1
1Leeds Institute of Cancer and Pathology, Wellcome Trust Brenner Building, St. James' University Hospital, Leeds, West Yorkshire, United Kingdom.
Abstract:
Progress in sequencing technology is intrinsically linked to progress in understanding cancer genomics. The purpose of this review was to discuss the development from Sanger sequencing to next-generation sequencing (NGS) technology. We highlight the technical considerations for understanding reports using NGS. We discuss the findings of studies in head and neck cancer using NGS as well as The Cancer Genome Atlas. Finally we discuss future routes for research utilizing this methodology and the potential impact of this. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2395-E2402, 2016.

