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Granulation techniques and technologies: recent progresses.

Srinivasan Shanmugam1

  • 1Pharm. R&D Institute, Hanmi Pharm. Co., Ltd., Hwasung, Gyeonggi, Korea.

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PubMed
Summary
This summary is machine-generated.

Pharmaceutical granulation transforms powders into compressible granules, facing challenges in quality and stability. This review explores innovative techniques like pneumatic dry granulation and foam granulation, highlighting their significance and limitations.

Keywords:
Granulation technique and technologyMoisture-activated dry granulationPneumatic dry granulationReverse wet granulationSteam granulationThermal adhesion granulation

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Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Materials Science

Background:

  • Granulation is a key unit operation in pharmaceutical manufacturing, essential for producing tablets and capsules.
  • It converts fine powders into larger, free-flowing granules, improving compressibility and handling.
  • Challenges include achieving content uniformity and desired physicochemical properties (size, density, porosity, hardness, moisture, compressibility) while ensuring drug stability.

Purpose of the Study:

  • To review recent advancements in pharmaceutical granulation techniques and technologies.
  • To provide an overview of innovative granulation methods, including their significance and limitations.
  • To highlight the evolving landscape of granulation technology in response to high quality requirements.

Main Methods:

  • The review focuses on novel granulation technologies.
  • Key techniques discussed include pneumatic dry granulation, reverse wet granulation, steam granulation, moisture-activated dry granulation, thermal adhesion granulation, freeze granulation, and foam granulation.
  • The study provides descriptions, significance, and limitations for each method.

Main Results:

  • Identified and described several innovative granulation techniques beyond traditional wet and dry methods.
  • Highlighted the significance and limitations of each novel granulation technology.
  • Emphasized the continuous evolution of pharmaceutical granulation technology.

Conclusions:

  • Novel granulation techniques offer potential solutions to challenges in achieving desired granule properties and drug stability.
  • The selection of an appropriate granulation process requires a deep understanding of drug-excipient properties and desired product characteristics.
  • Continued innovation in granulation technology is crucial for advancing pharmaceutical dosage form manufacturing.