Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spinal Cord: Gross Anatomy01:15

Spinal Cord: Gross Anatomy

7.5K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
7.5K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

6.4K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
6.4K
Spinal Nerves: Anatomy01:23

Spinal Nerves: Anatomy

11.6K
Spinal nerves are pivotal conduits in the nervous system, bridging the central nervous system (CNS) with the peripheral nervous system (PNS). These nerves enable a complex communication network between the brain, spinal cord, and the rest of the body, facilitating sensory input, motor output, and autonomic functions.
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
11.6K
The Spinal Cord01:54

The Spinal Cord

33.0K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
33.0K
Vascular Spasm01:16

Vascular Spasm

5.0K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histological and Top-Down Proteomic Analyses of the Visual Pathway in the Cuprizone Demyelination Model.

Journal of molecular neuroscience : MN·2022
Same author

The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis.

Glia·2022
Same author

Proteomics of Multiple Sclerosis: Inherent Issues in Defining the Pathoetiology and Identifying (Early) Biomarkers.

International journal of molecular sciences·2021
Same author

Minocycline Treatment Reduces Mass and Force Output From Fast-Twitch Mouse Muscles and Inhibits Myosin Production in C2C12 Myotubes.

Frontiers in physiology·2021
Same author

Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells.

Gut·2021
Same author

Pain Severity Correlates With Biopsy-Mediated Colonic Afferent Activation But Not Psychological Scores in Patients With IBS-D.

Clinical and translational gastroenterology·2021

Related Experiment Video

Updated: Apr 14, 2026

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique
07:17

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique

Published on: September 7, 2022

6.5K

Vascular changes associated with spinal root avulsion injury.

Vincent Cibert-Goton1, Justin P Phillips2, Peter J Shortland1,3

  • 1a Centre for Neuroscience & Trauma, Blizard Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London , London , UK .

Somatosensory & Motor Research
|April 23, 2015
PubMed
Summary
This summary is machine-generated.

Spinal root avulsion (SRA) injury does not significantly alter spinal cord blood flow or oxygen levels. This suggests ischemia may not be a primary driver of pain following SRA.

Keywords:
Avulsiondoppler flowmetryischemiapainphotoplethysmographyspinal cord

More Related Videos

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury
09:25

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury

Published on: December 31, 2017

10.0K
Contusion Spinal Cord Injury via a Microsurgical Laminectomy in the Regenerative Axolotl
07:16

Contusion Spinal Cord Injury via a Microsurgical Laminectomy in the Regenerative Axolotl

Published on: October 20, 2019

8.4K

Related Experiment Videos

Last Updated: Apr 14, 2026

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique
07:17

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique

Published on: September 7, 2022

6.5K
An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury
09:25

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury

Published on: December 31, 2017

10.0K
Contusion Spinal Cord Injury via a Microsurgical Laminectomy in the Regenerative Axolotl
07:16

Contusion Spinal Cord Injury via a Microsurgical Laminectomy in the Regenerative Axolotl

Published on: October 20, 2019

8.4K

Area of Science:

  • Neuroscience
  • Physiology
  • Pain Research

Background:

  • Spinal root avulsion (SRA) injury is associated with pain-like behaviors in rodents.
  • Altered blood flow is hypothesized to contribute to SRA-induced pain.

Purpose of the Study:

  • To investigate if spinal root avulsion (SRA) injury alters spinal cord blood flow (SCBF) and tissue oxygenation.
  • To determine the role of ischemia in SRA-induced pain-like behavior.

Main Methods:

  • Utilized photoplethysmography (PPG) and laser Doppler flowmetry (LDF) to measure SCBF in a rodent SRA model.
  • Recorded PPG and LDF signals 2 weeks post-injury, comparing ipsilateral and contralateral sides, rostral and caudal to the injury site.

Main Results:

  • No significant differences in SCBF were observed between SRA-injured and naive animals at or around the injury site.
  • Tissue oxygenation levels remained unchanged between groups along the rostrocaudal axis.
  • No significant differences in blood flow or oxygenation were found when comparing ipsilateral to contralateral sides.

Conclusions:

  • SRA injury does not appear to significantly impact spinal cord blood flow or oxygen levels.
  • Ischemia may play a less prominent role in the development of pain following SRA injury.