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Stabilization of disulfide linkage in drug-polymer-immunoglobulin conjugate by microenvironmental control
M Yokoyama1, T Okano, Y Sakurai
1Institute of Biomedical Engineering, Tokyo Women's Medical College, Japan.
Biochemical and Biophysical Research Communications
|November 15, 1989
Abstract:
The stability of disulfide linkage in the conjugate composed of the anti-cancer agent adriamycin, poly(ethylene glycol)-poly(aspartic acid) block copolymer, and immunoglobulin G was studied. The disulfide linkage between the block copolymer and immunoglobulin G was found to be resistant to reduction with dithiothreitol (DTT). This extraordinary resistance is considered to be brought about by steric hindrance of the poly(aspartic acid) chain binding adriamycin.