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Protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat
Hong-Min Wang1, Guo-Xing Li2, Han-Song Zheng1
1Center Hospital Affiliated to Zhengzhou University, Zhumadian 463000, China.
Objective:
To study the protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat.
Methods:
A total of 84 Wistar rats were divided into 4 groups: 12 in Group A (control group), 24 in Group B (diabetic cataract group), 24 in Group C (therapeutic-dose of resveratrol group) and 24 in Group D (low-dose of resveratrol group). Rats in Group B-D were given with 60 mg/kg streptozotocin through intraperitoneal injection. Rats in Group C were given with 100 mg/kg resveratrol and rats in Group D were given with 20 mg/kg resveratrol. The caspase-3 expression levels and apoptosis ratios of LEC among each group were observed; the degrees of lens opacity in Group B-D after 12 weeks were compared.
Results:
There were significant differences in caspase-3 expression levels, apoptosis ratios of LEC among groups at 4 w, 8 w and 12 w (P<0.05). After 12 weeks, in Group B the degree of lens opacity was as follow: 0 (0.00%) in grade I, 3 (37.50%) in grade II, 2 (25.00%)in grade III, 2 (25.00%)grade IV, and 1 (12.50%) in grade V; in Group C: 2 (25.00%)in grade I, 4 (50.00%) in grade II, 2 (25.00%)in grade III, 0 (0.00%)grade IV, and 0 (0.00 %) in grade V; in Group D: 1 (12.50%)in grade I, 4 (50.00%) in grade II, 2 (25.00%) in grade III, 1 (12.50%) grade IV, and 0 (0.00%) in grade V. The difference among Group B-D was statistically significant (P<0.05).
Conclusions:
Resveratrol has protective effect on lens epithelial cell apoptosis in diabetic cataract rat, and the effect is relative to its dose.
