Comparing Short-Duration Electro-Oculograms with and without Mydriasis in Healthy Subjects

Area of Science:

• Ophthalmology
• Neuroscience
• Medical Technology

Background:

• Artifact-free electro-oculogram (EOG) recordings typically require subject cooperation.
• Evaluating short-duration EOG recording characteristics is crucial for efficient clinical practice.
• The impact of mydriasis on EOG recording quality in controls needs further investigation.

Purpose of the Study:

• To assess the recording characteristics of short-duration electro-oculograms (EOG).
• To compare the effect of mydriasis on EOG recordings in a control cohort.
• To determine if mydriasis influences the quality of EOG data.

Main Methods:

• Electro-oculogram recordings were conducted using a RETI-port gamma plus2 system with a light-emitting diode stimulus screen.
• Standardized light and dark phases with specific fixation durations and sweep counts were employed.
• Recordings were analyzed for Arden ratio, dark-trough, and light-peak values, with statistical comparisons made between conditions with and without mydriasis, and across age groups.

Main Results:

• Fifty-five control participants were categorized into three age groups (18-20, 20-40, 40-60 years).
• No significant differences were found in Arden ratio, dark-trough, or light-peak between recordings with and without mydriasis (p > 0.05).
• Age and tested eye did not significantly influence the recorded EOG parameters.

Conclusions:

• Short-duration electro-oculograms are effective for obtaining high-quality recordings.
• Mydriasis does not adversely affect the quality or reliability of electro-oculogram recordings.
• These findings support the use of short-duration EOG with mydriasis in clinical settings.