Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

960
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
960
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

2.1K
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
2.1K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

2.7K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
2.7K
General Anesthesia: Overview01:24

General Anesthesia: Overview

1.1K
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
1.1K
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

1.0K
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Middy and Jim.

Anesthesiology·2026
Same author

Reply Re: antibiotic prophylaxis and risk of orbital cellulitis following orbital floor fracture: a real-world evidence study using the TriNetX network.

Orbit (Amsterdam, Netherlands)·2026
Same author

Antibiotic prophylaxis and risk of orbital cellulitis following orbital floor fracture: a real-world evidence study using the TriNetX network.

Orbit (Amsterdam, Netherlands)·2026
Same author

p120-catenin downregulation selectively modulates inflammatory susceptibility in eyelid specimens of rosacea.

Experimental eye research·2026
Same author

Severe Congenital Ptosis Repair: A Report by the American Academy of Ophthalmology.

Ophthalmology·2026
Same author

The Role of Corticosteroids in the Management of Orbital Cellulitis: A Report by the American Academy of Ophthalmology.

Ophthalmology·2026

Related Experiment Video

Updated: Apr 14, 2026

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells
13:12

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Published on: October 15, 2017

12.1K

Intravenous Acetaminophen in Orbital Surgery.

Edward J Wladis1, Dino F Kattato, Arup De

  • 1*Ophthalmic Plastic Surgery, Lions Eye Institute, Department of Ophthalmology, and †Department of Anesthesiology, Albany Medical College, Albany, New York, U.S.A.

Ophthalmic Plastic and Reconstructive Surgery
|April 23, 2015
PubMed
Summary

Intravenous acetaminophen (IVA) given before orbital surgery significantly reduced pain and the need for pain and nausea medications. IVA is effective in managing postoperative symptoms following orbital procedures.

More Related Videos

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

1.2K
A Neonatal Rodent Model of Retroorbital Vein Injection
04:39

A Neonatal Rodent Model of Retroorbital Vein Injection

Published on: February 23, 2024

10.5K

Related Experiment Videos

Last Updated: Apr 14, 2026

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells
13:12

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Published on: October 15, 2017

12.1K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

1.2K
A Neonatal Rodent Model of Retroorbital Vein Injection
04:39

A Neonatal Rodent Model of Retroorbital Vein Injection

Published on: February 23, 2024

10.5K

Area of Science:

  • Anesthesiology
  • Ophthalmology
  • Pharmacology

Background:

  • Orbital surgery can lead to significant postoperative pain and nausea.
  • Effective pain management is crucial for patient recovery and satisfaction after orbital procedures.

Purpose of the Study:

  • To evaluate the effectiveness of intravenous acetaminophen (IVA) in managing pain and nausea after orbital surgery.
  • To compare the outcomes of IVA administration at different time points relative to surgery.

Main Methods:

  • A prospective study involving 150 patients undergoing orbital surgery.
  • Patients were divided into three groups: control (no IVA), IVA within 30 minutes of surgery, and IVA immediately preoperatively.
  • Postoperative analgesic and anti-emetic medication requirements and standardized pain scores were recorded.

Main Results:

  • Patients receiving IVA preoperatively showed a significantly lower requirement for analgesic medications compared to the control group.
  • The control group experienced significantly higher pain scores and greater need for anti-emetic medications than the IVA groups.
  • IVA administration, particularly preoperatively, demonstrated a marked reduction in pain intensity and medication needs.

Conclusions:

  • Intravenous acetaminophen administered prior to orbital surgery is effective in reducing postoperative pain.
  • IVA significantly decreases the need for both analgesic and anti-emetic medications following orbital procedures.
  • Preoperative IVA administration offers substantial benefits for pain and nausea management in orbital surgery patients.