Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antispasmodic activity of tiropramide.

I Setnikar1, R Cereda, M A Pacini

  • 1Rotta Research Laboratorium, S.p.A., Monza, Italy.

Arzneimittel-Forschung
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrections to "Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors".

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Acute appendicitis: Factors associated with inconclusive ultrasound study and the need for additional computed tomography.

Diagnostic and interventional imaging·2018
Same author

Quantification of cells with specific phenotypes II: determination of CD4 expression level on reconstituted lyophilized human PBMC labelled with anti-CD4 FITC antibody.

Cytometry. Part A : the journal of the International Society for Analytical Cytology·2015
Same author

Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

Current medicinal chemistry·2011
Same author

Andolast acts at different cellular levels to inhibit immunoglobulin E synthesis.

International journal of immunopathology and pharmacology·2009
Same journal

Wirksamkeit und Verträglichkeit eines pflanzlichen Arzneimittels mit Kapuzinerkressenkraut und Meerrettich bei akuter Sinusitis, akuter Bronchitis und akuter Blasenentzündung im Vergleich zu anderen Therapien unter den Bedingungen der täglichen Praxis.

Arzneimittel-Forschung·2013
Same journal

Abstracts of the Paul-Martini-Stiftung Symposium 2012 in combination with the National Academy of Leopoldina. November 16-17, 2012. Berlin, Germany.

Arzneimittel-Forschung·2013
Same journal

Leave-one-out procedure in the validation of elimination rate constant analysis.

Arzneimittel-Forschung·2012
Same journal

Pharmacokinetic and myocardial enzyme profiles of two administration routes of epirubicin in breast cancer patients.

Arzneimittel-Forschung·2012
Same journal

Synthesis, anti-hypertensive effect of a novel angiotensin II AT1 receptor antagonist and its anti-tumor activity in prostate cancer.

Arzneimittel-Forschung·2012
Same journal

Effect of zeolite nano-materials and artichoke (Cynara scolymus L.) leaf extract on increase in urinary clearance of systematically absorbed nicotine.

Arzneimittel-Forschung·2012
See all related articles

Tiropramide hydrochloride demonstrates potent antispasmodic activity, particularly on pathological contractions, and is more effective than papaverine or flavoxate. While exhibiting some cardiovascular effects at high doses, it shows favorable toxicity profiles compared to papaverine.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Urology

Background:

  • Antispasmodic agents are crucial for managing gastrointestinal and urinary tract disorders.
  • Understanding the efficacy and safety profile of novel compounds like tiropramide hydrochloride is essential.

Purpose of the Study:

  • To evaluate the in vivo antispasmodic activities of tiropramide hydrochloride and its metabolites.
  • To compare the potency and safety of tiropramide with existing antispasmodic drugs.

Main Methods:

  • In vivo studies on various animal models including gastric emptying, intestinal motility, colonic motility, diarrhea, sphincter of Oddi spasm, and urinary bladder contractions.
  • Administration via intraperitoneal, intravenous, and oral routes.
  • Assessment of cardiovascular effects and toxicity (LD50).

Related Experiment Videos

Main Results:

  • Tiropramide hydrochloride exhibited significant antispasmodic activity across multiple models, with greater potency on pathological contractions.
  • It demonstrated higher potency than papaverine and flavoxate, with efficacy after oral administration.
  • Metabolites showed similar effects but lower potency; cardiovascular depression observed at high intravenous doses.
  • Tiropramide was less toxic than papaverine, and its metabolites were less toxic than the parent compound.

Conclusions:

  • Tiropramide hydrochloride is an effective eukinetic antispasmodic agent with a favorable potency and toxicity profile.
  • Cardiovascular effects may limit parenteral dosing in humans.
  • Further research into its therapeutic applications is warranted.