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Bioavailability of trapidil tablets.

M Weiss¹, W Sziegoleit, K Pönicke

¹Department of Pharmacology and Toxicology, Martin Luther University, Halle, German Democratic Republic.

Arzneimittel-Forschung

|September 1, 1989

Summary

Trapidil demonstrated complete bioavailability when administered orally or intravenously in healthy volunteers. Pharmacokinetic analysis revealed a mean absorption time of 66.4 minutes for oral trapidil (Rocornal).

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Area of Science:

Pharmacology
Pharmacokinetics

Background:

Trapidil is a vasodilator medication.
Understanding its absorption and bioavailability is crucial for therapeutic efficacy.

Purpose of the Study:

To determine the bioavailability of orally and intravenously administered trapidil.
To calculate the mean absorption time of oral trapidil.

Main Methods:

12 healthy volunteers received oral (200 mg) and intravenous (100 mg) doses of trapidil.
Serum trapidil concentrations were quantified using High-Performance Liquid Chromatography (HPLC).
Pharmacokinetic parameters were calculated using the method of curve moments.

Main Results:

Complete bioavailability was observed for oral trapidil.

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A mean absorption time of 66.4 minutes was calculated.

Intravenous administration served as a reference for bioavailability.

Conclusions:

Oral administration of trapidil results in complete absorption.
The calculated mean absorption time provides insight into the drug's absorption rate.
These findings support the oral route for trapidil administration.