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Interventions to Slow Aging in Humans: Are We Ready?
Valter D Longo1,2, Adam Antebi3, Andrzej Bartke4
1Davis School of Gerontology and Department of Biological Sciences, Longevity Institute, University of Southern California, Los Angeles, CA, 90089, USA.
Aging Cell
|April 24, 2015
Summary
Experts reached a consensus that interventions can slow human aging and prevent age-related diseases. Promising strategies include dietary changes and drugs targeting key aging pathways for extended healthspan.
Area of Science:
- Gerontology and longevity research.
- Translational medicine and therapeutic interventions.
Background:
- A workshop convened experts to discuss interventions for slowing human aging and extending healthspan.
- Existing evidence suggests aging interventions can delay chronic diseases in adults and the elderly.
Purpose of the Study:
- To achieve expert consensus on the discovery and development of safe interventions to slow aging.
- To identify promising strategies for human testing to improve healthspan.
Main Methods:
- Consensus-building among leading experts in aging biology and genetics.
- Review of evidence from model organisms and rodents for pro-longevity effects.
- Selection of promising interventions for human healthspan extension.
Main Results:
- Consensus that aging interventions can delay disease onset and improve healthspan.
- Identification of key aging pathways and potential intervention strategies.
- Selection of four promising intervention categories for human testing.
Conclusions:
- Dietary interventions (e.g., fasting-mimicking diets) show potential for slowing aging.
- Pharmacological interventions targeting growth hormone/IGF-I, mTOR-S6K, AMPK, or sirtuins are promising.
- These interventions, based on animal studies, may safely extend human healthspan and prevent age-related diseases.
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