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Updated: Apr 14, 2026
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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
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Sigma-1 receptor and inflammatory pain
Georgia Gris1, Enrique José Cobos, Daniel Zamanillo
1Drug Discovery and Preclinical Development, ESTEVE, Baldiri Reixach, 4-8, 08028, Barcelona, Spain.
Summary
Blocking the sigma-1 receptor (Sig-1R) with antagonists shows promise for treating inflammatory pain. Sig-1R antagonists effectively reduced pain hypersensitivity in preclinical models, suggesting a new therapeutic avenue.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- The sigma-1 receptor (Sig-1R) is a molecular chaperone modulating protein targets like GPCRs and ion channels.
- Sig-1R is present in pain-controlling areas of the nervous system.
- Previous research suggested Sig-1R antagonists for neuropathic pain.
Purpose of the Study:
- To explore the role of Sig-1R in inflammatory pain.
- To summarize recent findings on Sig-1R antagonists in inflammatory pain models.
Main Methods:
- Utilized pharmacological and genetic tools to investigate Sig-1R.
- Examined phenotypic responses in Sig-1R knockout mice.
- Administered Sig-1R antagonists (e.g., S1RA) systemically and peripherally in preclinical models.
Main Results:
- Mice lacking Sig-1R exhibited altered responses to inflammatory injury.
- Sig-1R antagonists inhibited mechanical and thermal hypersensitivity.
- These effects were observed in multiple preclinical models of inflammatory pain.
Conclusions:
- Sig-1R plays a role in inflammatory pain conditions.
- Pharmacological blockade of Sig-1R is a potential therapeutic strategy.
- Central and peripheral Sig-1R antagonism may effectively treat inflammatory pain.
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