Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

9.4K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
9.4K
Global Regulatory Systems01:28

Global Regulatory Systems

927
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
927
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

8.4K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability.

International journal of pharmaceutics: X·2026
Same author

From brown to white: Brown adipose tissue endothelial cells whiten in culture conditions.

Molecular metabolism·2026
Same author

Endothelial ADGRF5(GPR116) governs vascular adaptation required for sustained thermogenic remodeling of brown adipose tissue.

Molecular metabolism·2026
Same author

Shiny-Calorie: a context-aware application for indirect calorimetry data analysis and visualization using R.

Bioinformatics advances·2026
Same author

Antibiotic-Mediated Modulation of the Gut Microbiome Identifies Taurine as a Modulator of Adipocyte Function Through TGR5 Signaling.

International journal of molecular sciences·2026
Same author

ENT1 inhibition enhances weight control and metabolic health in diet-induced obesity.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025

Related Experiment Video

Updated: Apr 14, 2026

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
07:22

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

39.7K

cGMP and Brown Adipose Tissue.

Linda S Hoffmann1, Christopher J Larson2, Alexander Pfeifer3,4,5

  • 1Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127, Bonn, Germany.

Handbook of Experimental Pharmacology
|April 24, 2015
PubMed
Summary
This summary is machine-generated.

Cyclic guanosine monophosphate (cGMP) is crucial for brown adipose tissue (BAT) function. Targeting cGMP signaling offers a promising strategy for obesity treatment by enhancing BAT

Keywords:
Brown adipose tissueInducible brown adipocytesPDE5 inhibitorsPKGIThermogenesisUCP1White adipose tissuecGMPsGC

More Related Videos

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

13.9K
Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention
02:55

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention

Published on: October 6, 2023

2.2K

Related Experiment Videos

Last Updated: Apr 14, 2026

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
07:22

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

39.7K
Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

13.9K
Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention
02:55

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention

Published on: October 6, 2023

2.2K

Area of Science:

  • Biochemistry
  • Metabolism
  • Cell Biology

Background:

  • Cyclic guanosine monophosphate (cGMP) is a vital second messenger in physiological processes.
  • Brown adipose tissue (BAT) plays a key role in energy expenditure and thermogenesis.
  • cGMP's role in metabolism, particularly in BAT, is an emerging area of research.

Purpose of the Study:

  • To review the fundamental role of cGMP in brown adipose tissue (BAT) differentiation and function.
  • To highlight recent findings on the physiological significance of cGMP signaling in BAT.
  • To explore pharmacological strategies targeting cGMP for obesity treatment.

Main Methods:

  • Literature review of studies investigating cGMP signaling in BAT.
  • Analysis of molecular pathways involving cGMP, guanylyl cyclases, and phosphodiesterases.
  • Examination of cGMP's downstream effects on brown adipocyte activation and function.

Main Results:

  • cGMP signaling is essential for BAT differentiation and function.
  • Activation of the cGMP pathway enhances BAT's energy-combusting properties.
  • Pharmacological targeting of cGMP signaling shows potential for BAT-centered obesity therapies.

Conclusions:

  • cGMP plays a critical role in regulating BAT's thermogenic capacity.
  • Modulating cGMP signaling in BAT presents a promising therapeutic avenue for combating obesity.
  • Further research into cGMP pathways could lead to novel anti-obesity treatments.