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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
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Complex regional pain syndrome type I: a comprehensive review
M Bussa1, D Guttilla1, M Lucia2
1O.U. of Anesthesia, Intensive Care and Pain Therapy of Sant'Antonio Abate Hospital, Casa Santa Erice, Trapani, Italy.
Acta Anaesthesiologica Scandinavica
|April 24, 2015
Summary
Early diagnosis and multidisciplinary treatment are crucial for managing complex regional pain syndrome type I (CRPS I). Physical therapy is a recommended first-line treatment, though pharmacological options remain empirical and insufficiently effective for CRPS I.
Area of Science:
- Pain Medicine
- Neurology
Background:
- Complex Regional Pain Syndrome type I (CRPS I), previously reflex sympathetic dystrophy (RSD), is a chronic pain condition following limb injury.
- Pathophysiology involves inflammation and neuroplasticity, with altered central processing of nociceptive input.
- CRPS I is a multifactorial disorder impacting adult patients.
Purpose of the Study:
- To provide a synopsis of CRPS I, including current understanding, diagnosis, and treatment options.
- To review the limited evidence available in medical literature regarding CRPS I management.
Main Methods:
- A literature search was performed using the Medline database.
- The search covered publications from 1980 to 2014.
Main Results:
- Early diagnosis and multidisciplinary treatment are essential to prevent long-term disability.
- Physical therapy is widely recommended as a primary treatment approach.
Conclusions:
- Pharmacological treatments for CRPS I are empirical and often lack sufficient efficacy.
- Further research is needed to evaluate therapeutic modalities; the effectiveness of local anesthetic sympathetic blockade is uncertain.
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