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Use of the crushing strength parameter for quality control of phenobarbital-microcrystalline cellulose tablets
C Souto1, J L Gómez-Amoza, M Landín
1Departamento De Farmacología, Farmacia Y Technología Farmacéutica Facultad De Farmacia, Santiago De Compostela, Spain.
Farmaco (Societa Chimica Italiana : 1989)
|July 1, 1989
Abstract:
Three variables of the tablet manufacturing process (duration of mixing with lubricant, maximum compression force and compression rate) were studied for their effects on various properties of direct compression phenobarbital-microcrystalline cellulose tablets. Mixing time and maximum compression force were found to have a marked influence on friability and dissolution rate; crushing strength was found to be a useful parameter for quality control.