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Published on: September 20, 2024
Serotonin transporter gene polymorphisms: Relation with platelet serotonin level in patients with primary Sjogren's
J Markeljevic1, H Sarac2, N Bozina3
1Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sestre milosrdnice, HR-Vinogradska cesta 29, 10000 Zagreb, Croatia.
Abstract:
Significantly lower platelet serotonin level (PSL) in patients with primary Sjogren's syndrome (pSS) than in healthy controls has been reported in our prior studies. In the present report, we demonstrated effect of functional polymorphisms in the serotonin transporter gene (5-HTT) on PSL. We describe a group of 61 pSS patients and 100 healthy individuals subjects, who received PSL measurement in our prior study. All subjects were genotyped for the promoter 5-HTTLPR (L/S), rs25531 (A/G) and intronic 5-HTTVNTRin2 (l/s) polymorphisms. Overall, the presence of 5-HTTVNTRin2 ss genotype was associated with significantly lower PSL in pSS patients, not in healthy controls. Reduced PSL in pSS patients is in line with hypothesis of association between chronic immunoinflammation and 5-HT system dysregulation, identifying additional mechanisms such as altered 5-HT transport as potential genetic factor contributing to PSL depletion.
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