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Related Experiment Videos

Lexical processing in Parkinson's disease and multiple sclerosis.

W W Beatty1, N Monson

  • 1Neuropsychiatric Research Institute, Fargo, ND 58107.

Journal of Geriatric Psychiatry and Neurology
|July 1, 1989
PubMed
Summary
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Patients with Parkinson's disease (PD) and multiple sclerosis (MS) can experience impaired naming, even with mild cognitive changes. These naming difficulties, particularly in semantic tasks, highlight language challenges in subcortical neurological disorders.

Area of Science:

  • Neuroscience
  • Neurolinguistics
  • Cognitive Psychology

Background:

  • Subcortical neurological diseases like Parkinson's disease (PD) and multiple sclerosis (MS) can affect cognitive functions.
  • Language impairments, specifically naming deficits, are increasingly recognized in these conditions, even when global mental status is only mildly affected.

Purpose of the Study:

  • To investigate naming abilities in patients with PD and MS.
  • To compare naming performance between patients with normal naming (NN) and impaired naming (IN) within these disease groups.
  • To explore the nature of naming deficits and their relationship to other cognitive functions.

Main Methods:

  • Categorized patients with PD and MS into normal naming (NN) and impaired naming (IN) groups based on the Boston Naming Test.

Related Experiment Videos

  • Administered tests assessing naming with semantic, visual, or rhyming cues.
  • Assessed vocabulary and sentence repetition using the Wechsler Adult Intelligence Scale-Revised and other tasks.
  • Ensured all patients had a Mini-Mental State Examination score of at least 23.

    • Main Results:

    • Patients with impaired naming in both PD (PDIN) and MS (MSIN) groups showed significant difficulties in naming when cues were provided.
    • PDIN and MSIN groups also performed poorly on vocabulary and sentence repetition tasks.
    • Patients with normal naming (PDNN, MSNN) exhibited more selective cognitive deficits.

    Conclusions:

    • Naming abilities can be compromised in subcortical diseases like PD and MS, even with mild cognitive impairment.
    • Language, particularly naming, is vulnerable in these neurological conditions.
    • The precise clinical implications of these naming deficits require further investigation.