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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
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Ocular manifestations in systemic lupus erythematosus
Sukhum Silpa-archa1, Joan J Lee2, C Stephen Foster3
1Massachusetts Eye Research and Surgery Institution, Cambridge, Massachusetts, USA Ocular Immunology & Uveitis Foundation, Cambridge, Massachusetts, USA Faculty of Medicine, Department of Ophthalmology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
The British Journal of Ophthalmology
|April 24, 2015
Summary
Systemic lupus erythematosus (SLE) commonly affects the eyes, potentially causing blindness. Early diagnosis and treatment of ocular lupus are crucial for preserving vision and reducing complications.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) frequently involves ocular structures, including the eyelid, conjunctiva, sclera, cornea, uvea, retina, and optic nerve.
- Ocular manifestations are common in SLE patients and can lead to irreversible vision loss due to the disease or its treatments.
- Keratoconjunctivitis sicca is the most prevalent ocular finding, though retinal, choroidal, and optic nerve involvement pose significant risks to vision.
Purpose of the Study:
- To review the ocular manifestations of SLE.
- To highlight the correlation between ocular symptoms and systemic disease activity.
- To discuss current and potential therapeutic strategies for ocular lupus.
Main Methods:
- Literature review of ocular manifestations in Systemic Lupus Erythematosus.
- Analysis of the relationship between ocular symptoms and systemic disease activity.
- Evaluation of established and emerging treatment modalities for ocular lupus.
Main Results:
- Ocular involvement in SLE is diverse, affecting multiple eye components.
- Vision loss can result from retinal, choroidal, and optic nerve complications.
- Ocular symptoms can be an early indicator of SLE and are linked to disease activity.
Conclusions:
- Prompt diagnosis and management of ocular SLE are essential to prevent visual morbidity.
- Integrated treatment approaches combining systemic therapies (corticosteroids, immunosuppressants, biologics) and local ocular treatments are effective.
- Early recognition and intervention significantly reduce the risk of permanent vision loss in SLE patients.
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