Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.

Neurobiology of disease·2026
Same author

The root cause: why do so many drugs fail to translate from bench to bedside?

Expert opinion on drug discovery·2026
Same author

Cancer signaling beyond the genes.

Current opinion in cell biology·2026
Same author

Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states.

Developmental cell·2026
Same author

The hierarchical timescale hypothesis: Functional and structural convergence of biological networks and artificial neural nets.

Cell systems·2026
Same author

Harnessing the Power of <i>Drosophila</i> Primordial Germ Cell Migration.

Cold Spring Harbor perspectives in biology·2026
Same journal

Discerning dangerous gain of function: most gain of function (GoF) research does not involve infectious microbes.

Frontiers in bioengineering and biotechnology·2026
Same journal

Microtopography screening to modulate the mitogenic effects of aqueous humor on human tenon fibroblasts.

Frontiers in bioengineering and biotechnology·2026
Same journal

Next-generation strategies for anterior cruciate ligament repair: constructing biointelligent ligament grafts integrating biomimetic design, immune modulation, and sensory feedback.

Frontiers in bioengineering and biotechnology·2026
Same journal

Collagen nanofiber reinforced alginate hydrogel tube microbioreactors for cell culture.

Frontiers in bioengineering and biotechnology·2026
Same journal

Calcium ions released from alginate hydrogel promote wound healing by enhancing fibroblast activity.

Frontiers in bioengineering and biotechnology·2026
Same journal

Application and validation of AI-assisted 3D-Printed gastroduodenal anatomical variation models in specialized nursing training.

Frontiers in bioengineering and biotechnology·2026
See all related articles

Related Experiment Video

Updated: Apr 14, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

22.0K

Spatial manipulation with microfluidics.

Benjamin Lin1, Andre Levchenko1

  • 1Department of Biomedical Engineering, Systems Biology Institute, Yale University , West Haven, CT , USA.

Frontiers in Bioengineering and Biotechnology
|April 24, 2015
PubMed
Summary
This summary is machine-generated.

Biochemical gradients guide cell behaviors like differentiation and migration. Microfluidic devices precisely control these gradients for in vitro studies, advancing biological research.

Keywords:
cell migrationchemotaxisgradientsmicrofluidicssoft lithography

More Related Videos

Microfluidic Pneumatic Cages: A Novel Approach for In-chip Crystal Trapping, Manipulation and Controlled Chemical Treatment
09:34

Microfluidic Pneumatic Cages: A Novel Approach for In-chip Crystal Trapping, Manipulation and Controlled Chemical Treatment

Published on: July 12, 2016

10.1K
Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

1.7K

Related Experiment Videos

Last Updated: Apr 14, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

22.0K
Microfluidic Pneumatic Cages: A Novel Approach for In-chip Crystal Trapping, Manipulation and Controlled Chemical Treatment
09:34

Microfluidic Pneumatic Cages: A Novel Approach for In-chip Crystal Trapping, Manipulation and Controlled Chemical Treatment

Published on: July 12, 2016

10.1K
Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

1.7K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Biophysics

Background:

  • Biochemical gradients are crucial signaling molecules in biological systems.
  • Understanding gradient dynamics is key to development, homeostasis, and disease.
  • Cellular responses to gradients include differentiation, proliferation, and migration.

Purpose of the Study:

  • To review the utility of microfluidic technologies for studying biochemical gradient sensing.
  • To highlight applications of microfluidic gradient sensing in biological research.

Main Methods:

  • Microfluidic devices enable precise control of fluid dynamics at the cellular scale.
  • Controlled generation and manipulation of biochemical gradients in vitro.
  • In vitro experimental setups for observing cellular responses to gradients.

Main Results:

  • Microfluidics allows for the creation of stable and tunable biochemical gradients.
  • Enables high-resolution spatial and temporal control over gradient profiles.
  • Facilitates detailed analysis of cellular responses to defined gradients.

Conclusions:

  • Microfluidic technologies are indispensable tools for in vitro gradient sensing research.
  • These technologies significantly advance our understanding of how cells interpret spatial information.
  • Applications span various biological fields, from developmental biology to disease modeling.