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Published on: February 8, 2022
Diffusion-weighted imaging of the kidneys and its relationship with residual renal function in continuous ambulatory
Ling Yang1, Xue-Ming Li, Shuang Zhao
11 Department of Radiology, West China Hospital, Sichuan University, 37 Guoxue St, Chengdu 610041, Sichuan Province, China.
Objective:
The objective of our study was to prospectively evaluate renal diffusion as shown by diffusion-weighted imaging (DWI) and its relationship with the residual renal function (RRF) in continuous ambulatory peritoneal dialysis (CAPD) patients.
Subjects And Methods:
Forty CAPD patients and 40 healthy volunteers were recruited, and all underwent conventional and fat-saturated echo-planar DWI with three b values (0, 300, 600 s/mm(2)). The renal parenchymal thickness and apparent diffusion coefficients (ADCs) were measured, and both were compared between the two groups. The relationships between ADC values and clinical indexes--which included RRF, serum creatinine value, cystatin C value, and urine output--were analyzed.
Results:
Compared with the renal parenchymal thickness and ADC values in control subjects, these values in CAPD patients were significantly decreased (p < 0.0001). In CAPD patients, the ADC values were positively correlated with RRF (r = 0.447, p = 0.004). A mild linear correlation was also found between the ADC values and cystatin C value (r = -0.352, p = 0.026).
Conclusion:
The renal diffusion function as shown by DWI is impaired in CAPD patients and correlates with RRF.
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