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Relation between renal function tests and a retrospective organic solvent exposure score.

P Hotz¹, J Pilliod, D Söderström

¹Institute of Occupational Health Sciences, Lausanne, Switzerland.

British Journal of Industrial Medicine

|November 1, 1989

Summary

This study validated an occupational exposure score for organic solvents. The score showed relations with kidney function tests like N-acetyl-beta-D-glucosaminidase (NAG) activity and erythrocyturia in exposed workers.

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Area of Science:

Occupational Health
Nephrology
Toxicology

Background:

Occupational exposure to organic solvents is a concern for kidney health.
Existing methods to quantify solvent exposure, like self-reported occupational history scores, lack validation.
Assessing the relationship between exposure scores and kidney function is crucial for understanding occupational risks.

Purpose of the Study:

To validate a cumulative exposure score for organic solvents.
To examine the association between this exposure score and various kidney function tests in a worker population.

Main Methods:

A case-control study design was employed.
Exposure to organic solvents was assessed using a validated occupational history score.
Kidney function was evaluated through tests including N-acetyl-beta-D-glucosaminidase (NAG) activity, erythrocyturia, albuminuria, protein creatinine ratio, and leucocyturia.

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Main Results:

The study found significant relations between the exposure score and N-acetyl-beta-D-glucosaminidase (NAG) activity.
Associations were also observed for erythrocyturia and potentially albuminuria.
No significant relations were found for the protein creatinine ratio or leucocyturia.

Conclusions:

The validated occupational exposure score demonstrates potential utility in assessing kidney function changes related to organic solvent exposure.
NAG activity and erythrocyturia appear to be sensitive indicators of kidney effects from solvent exposure.
Further research may refine the score's application and explore other biomarkers.