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Stroke in young with primary protein--S deficiency

Narayana Pantam, Mamatha Pulloori, Keerthi Alugubelly

    The Journal of the Association of Physicians of India
    |April 25, 2015
    PubMed

    Insights

    Young stroke patients often have thrombophilic disorders. This case highlights isolated Protein-S deficiency as a significant risk factor for stroke in a young adult.

    Area of Science:

    • Neurology
    • Vascular Medicine
    • Genetics

    Background:

    • Stroke in young adults is a significant health concern, particularly in developing nations, with prevalence rates of 25-34% in India.
    • Thrombophilic disorders are identified as the cause in 60% of stroke cases with undetermined etiology.

    Observation:

    • A 20-year-old female presented with symptoms indicative of left Posterior Cerebral Artery (PCA) thrombosis, specifically P2 syndrome.
    • Diagnostic evaluation revealed an isolated Protein-S deficiency as the sole identified risk factor.

    Findings:

    • The case demonstrates a direct correlation between isolated Protein-S deficiency and the occurrence of stroke in a young individual.
    • Protein-S deficiency was identified as the primary etiological factor for the patient's stroke.

    Implications:

    • This case underscores the importance of screening for thrombophilic disorders, such as Protein-S deficiency, in young stroke patients.
    • Early diagnosis and management of Protein-S deficiency can potentially prevent recurrent stroke events in susceptible populations.
    • Further research into the prevalence and impact of Protein-S deficiency in young stroke etiology is warranted.

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