hOGG1 C1245G gene polymorphism associated with prostate cancer: a meta-analysis

Prostate cancer (Pca) is one of the most frequently encountered multifactorial malignant diseases worldwide. The human oxoguanine glycosylase 1 (hOGG1) C1245G polymorphism (rs1052133) has been found to be associated with Pca. However, the conclusions have been controversial.

Based on the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases, this meta-analysis was conducted with 4 models. Eleven qualified studies were included.

Although no positive relation was discovered in the pooled analysis, significant associations between rs1052133 and Pca were found in the Asian population (recessive: odds ratio [OR] = 1.580, 95% confidence interval [95% CI], 1.189-2.098; GG vs. GC: OR = 1.504, 95% CI, 1.114-2.030; GG vs. CC: OR = 1.677, 95% CI, 1.201-2.342; allele analysis: OR = 1.249, 95% CI, 1.077-1.449), whites (dominant: OR = 2.138, 95% CI, 1.483-3.083; recessive: OR = 3.143, 95% CI, 1.171-8.437; GG vs. CC: OR = 3.992, 95% CI, 1.891-8.431; allele analysis: OR = 1.947, 95% CI, 1.467-2.586) and mixed populations (recessive: OR = 0.636, 95% CI, 0.484-0.834; GG vs. GC: OR = 0.654, 95% CI, 0.492-0.871; GG vs. CC: OR = 0.624, 95% CI, 0.473-0.823; allele analysis: OR = 0.857, 95% CI, 0.771-0.954). After excluding studies deviating from the Hardy-Weinberg equilibrium, a significant association was also found in the same ethnic groups. In addition, a new positive relation was identified in the "other country" subgroup (with China, South Korea and Australia included) (dominant: OR = 1.622, 95% CI, 1.163-2.261; recessive: OR = 1.773, 95% CI, 1.308-2.404; GG vs. GC: OR = 1.614, 95% CI, 1.169-2.230; GG vs. CC: OR = 2.108, 95% CI, 1.456-3.051; allele analysis: OR = 1.494, 95% CI, 1.235-1.808) and among the Chinese-Korean population.

In conclusion, we suggest that the hOGG1 C1245G polymorphism might be potentially associated with Pca risk in different ethnicities and countries, especially among Asians. Further studies are needed to confirm these relations.